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Microsatellite mutation rates are equivalent in normal and telomerase-immortalized human fibroblasts
Telomerase-expressing human fibroblasts generally have the same properties as normal cells, except that they have an indefinite life span in culture. We have introduced a dinucleotide repeat sequence into the telomerase-expressing hTERT-1604 cell line and characterized the rates and types of frameshift mutations within this microsatellite. These data have been compared with those in diploid fibroblasts with a finite life span. The rates of mutation were found to be similar in the two cellpmid:11731418 fatcat:m2oy7azgbvdxfjtio7d7wxhnni