In Ayurveda a person is said to be healthy when Dosha, Agni, Dhatu, all the physiological process are in homeostatic state and soul, sense organ and mind are in a state of total wellbeing. Theory of tridosha is a unique concept to Ayurveda. Pitta dosha plays a major role in digestion and metabolism. Pitta doshas are of five types namely pachaka, ranjaka, alochaka, bhrajaka, and sadhaka pitta. The seat of Sadhaka pitta is hridaya and it is associated with mental faculties and emotions. These

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... tions can be recognized as functions of higher center of brain which is carried out by small molecule, rapidly acting transmitters and neuropeptides or slowly acting neurotransmitters. Few works have been mentioned on conceptual features of pitta. In this article a correlation of the physiological activity of sadhaka pitta with modern medical science has been mentioned.