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Dimensional reduction of phenotypes from 53,000 mouse models reveals a diverse landscape of gene function
[article]
2021
bioRxiv
pre-print
Animal models have long been used to study gene function and the impact of genetic mutations on phenotype. Through the research efforts of thousands of research groups, systematic curation of published literature, and high-throughput phenotyping screens, the collective body of knowledge for the mouse now covers the majority of protein-coding genes. We here collected data for over 53,000 mouse models with mutations in over 15,000 genomic markers and characterized by more than 254,000 annotations
doi:10.1101/2021.06.10.447851
fatcat:56jthopkrrf3dktd7qiwrn6jjy