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Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats
Biphalin expresses almost equal affinity for µ-and d-opioid receptors. The aim of this study was to delineate a possible role of d-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 µmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of d-opioid receptors with naltrindole (4.2doi:10.1016/s1734-1140(11)70644-2 pmid:22180367 fatcat:25n6aevm5bfehkqimhbrhgs2yy