Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats

Wojciechowski Piotr, Szereda-Przestaszewska Małgorzata, Lipkowski Andrzej W.
2011 Pharmacological Reports  
Biphalin expresses almost equal affinity for µ-and d-opioid receptors. The aim of this study was to delineate a possible role of d-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in anesthetized, spontaneously breathing rats. In control animals, an intravenous bolus of biphalin (0.3 µmol/kg) evoked apnea, followed by a decreased breathing rate and increased tidal volume, hypotension and bradycardia. Blockade of d-opioid receptors with naltrindole (4.2
more » ... ) significantly reduced the duration of apnea, slowdown of respiration, immediate post-challenge hypotension and bradycardia induced by biphalin administration. These results indicate that the activation of d-opioid receptors adds to the depressive response produced by biphalin.
doi:10.1016/s1734-1140(11)70644-2 pmid:22180367 fatcat:25n6aevm5bfehkqimhbrhgs2yy