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Water metabolism disturbances at different stages of primary thyroid failure
Journal of Endocrinology
The aim of the present study was to study salt and water metabolism in thyroid deficiency. We performed an oral water loading test (OWL) and a hypertonic 5% saline infusion test (HSI) in 16 patients with overt primary hypothyroidism before replacement treatment (PRE group) and after, in eight patients with subclinical hypothyroidism (SUB group) and in 16 normal individuals (CG group). In the PRE group, a lower free water clearance was detected in the OWL (P<0•022), with lower plasma osmolalitydoi:10.1677/joe.0.1680435 pmid:11241175 fatcat:fi5e5d5wejhotoagrum7pgpd2y