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Conclusion: Our DIR-QA platform demonstrated inter-and intra-operator variability on the order of one voxel (1mm by 1mm by 2.5mm). Machine-generated feature points can serve as a measure of the quality of deformable image registration.doi:10.1016/s0167-8140(16)33153-x fatcat:usyyfc43afhczbf5a3eoe3dmtq