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Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons
Pathophysiological damages and loss of function of dopamine neurons precedes their demise and contributes to the early phases of Parkinson's disease. The presence of aberrant intercellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one of the cardinal features of Parkinson's disease. We employed multiple complementary approaches in molecular biology, electrophysiology, and live-cell imaging to investigate how excessive α-synuclein levelsdoi:10.1101/2021.03.30.437775 fatcat:a43vvchpbrfurefctxf23izzaa