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Plasmin-mediated cleavage of EphA4 at central amygdala inhibitory synapses controls anxiety
[article]
2021
bioRxiv
pre-print
Severe stress can trigger complex behavioural changes such as high anxiety (1). Inhibitory GABA-ergic interneurons in the lateral division of the central amygdala (CEl) control anxiety through feedforward inhibition of their target cells in the medial division (CEm) (2, 3). In particular, PKCδ-positive (PKCδ+) interneurons in CEl are critical elements of the neuronal circuitry of fear and anxiety (3-5), but the molecular mechanisms they employ are poorly understood. Here, we show that, during
doi:10.1101/2021.07.16.452595
fatcat:x3supoy5n5b2rebl3s75mclmfq