In Iran, human immunodeficiency virus (HIV) is a stigmatized issue and there is a nega tive attitude towards the disease. The stigma and discrimination because of HIV can affect both physical and mental health, social activities, and the quality of life of HIVpositive people. The aim of this study was to evaluate the attitude towards HIV infection among people living with HIV (PLHIV) in Isfahan, Iran. Material and methods: This crosssectional study examined 99 HIVpositive patients from the

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... an Health Center, Isfahan, Iran, in December 2017. A standard questionnaire through a crosssectional study was used to evaluate the attitude concerning HIV infection among PLHIV. In addition, linear regression was used to assess factors affecting attitude among PLHIV. Results: About 24% of participants had good levels of attitude, whereas 67.71% of them had a moderate attitude. In addition, around 93% of respondents believed that to allow PLHIV to joint freely in all social activities. The evaluated factors such as gender (p = 0.28), age (p = 0.96), educational level (p = 0.83), and marital status and occupation (p = 0.58), did not have a significant relationship with the attitude score. Conclusions: The attitude to HIV infection was not satisfactory among PLHIV in Isfahan, considering that HIV/AIDSrelated stigma can cause personal, familial, and social problems. Therefore, appropriate actions are needed to improve the attitude and to reduce stigma associated with HIV infection.