A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is
Primary cilia control glucose homeostasis via islet paracrine interactions
Proceedings of the National Academy of Sciences of the United States of America
Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-secreting cells. What underlies the function of the islet as a unit is the close approximation and communication among heterogeneous cell populations, but the structural mediators of islet cellular cross talk remain incompletely characterized. We generated mice specifically lacking β-cell primary cilia, a cellular organelle that has been implicated in regulating insulin secretion, and found that the β-celldoi:10.1073/pnas.2001936117 pmid:32253320 fatcat:khe7ncajpfdr7gczy4di36tqmi