Impact of Rotavirus Vaccination on Diarrhea-related Hospitalizations Among Children <5 Years of Age in Mexico

Manjari Quintanar-Solares, Catherine Yen, Vesta Richardson, Marcelino Esparza-Aguilar, Umesh D. Parashar, Manish M. Patel
2011 The Pediatric Infectious Disease Journal  
in Mexican children Ͻ5 years of age. We compared diarrhea-related hospitalizations during the 2008 and 2009 rotavirus seasons with the median number of diarrhea-related hospitalizations at baseline (2003-2006), before rotavirus vaccine introduction, at 306 Ministry of Health hospitals. We estimated vaccine coverage using administrative data. Results: A median number of 10,993 diarrhea-related hospitalizations (range: 9877-11958) occurred each prevaccine rotavirus season from 2003 to 2006 among
more » ... 2003 to 2006 among children Ͻ5 years of age. Diarrhea-related hospitalizations decreased by 11% (N ϭ 9836) in 2008 and by 40% (N ϭ 6597) in 2009. The greatest declines occurred in infants Ͻ12 months of age during 2008 (25%) and 2009 (52%), with 1-dose rotavirus vaccination coverage of 74% and 89% during these years, respectively. A 43% decline was also noted among children 12 to 23 months of age during the 2009 season. No declines were noted during either 2008 or 2009 among unvaccinated children Ͼ24 months of age during the study period. Conclusions: Marked declines in diarrhea-related hospitalizations among vaccine-eligible Mexican children Ͻ24 months of age have occurred during the first 2 complete rotavirus seasons following rotavirus vaccination. Rotavirus-specific surveillance and epidemiologic studies are necessary for a better understanding of the changes in disease epidemiology and public health impact from rotavirus vaccination.
doi:10.1097/inf.0b013e3181fefb32 pmid:21183834 fatcat:mpndpithyzhhhn7mey5mxopbky