A monoclonal antibody specific for the cellular receptor for the group B coxsackieviruses

K H Hsu, K Lonberg-Holm, B Alstein, R L Crowell
1988 Journal of Virology  
A 50-kilodalton receptor protein (Rp-a) for the group B coxsackieviruses (CB) was isolated in a virusreceptor complex from detergent-solubilized HeLa cells (J. E. Mapoles, D. L. Krah, and R. L. Crowell, J. Virol. 55:560-566, 1985). It was used as an immunogen for preparation of a mouse monoclonal antibody (RmcB) which protected HeLa cells and Buffalo green monkey kidney cells from infection by all six serotypes of CB. RmcB did not protect HeLa cells from infection by poliovirus, echovirus 6, or
more » ... coxsackievirus A18. This monoclonal antibody differed in receptor epitope specificity from a previously isolated antibody (RmcA) (R. L.
doi:10.1128/jvi.62.5.1647-1652.1988 fatcat:tmjlerwydbcd7exjkuajuz5bvq