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Disruption of the 37-kDa/67-kDa laminin receptor gene in bovine fetal fibroblasts
2012
African Journal of Biotechnology
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The 37-kDa/67-kDa laminin receptor (LRP/LR), also known as ribosomal protein SA (RPSA), acts as a cell surface receptor for prions and plays an important role in internalization of cellular prion protein. In this study, we knocked out the part of prion binding sites (aa 161-205) by gene targeting in the bovine fetal fibroblasts (BFF). This is the first report about disrupting the gene encoding for the prion binding site in bovine fetal fibroblasts. The heterozygous BFF are ready to be used in
doi:10.5897/ajb11.4005
fatcat:3jmfghfi7vfhxj5b2ngo74gj2e