The evolution of medical research: from trials to tailored therapy
L'evoluzione della ricerca medica: dai trial alla terapia personalizzata

Evasio Pasini, Salvatore Pirelli, Andrea Di Lenarda, Francesco S Dioguardi, Attilio Maseri
2010 Giornale Italiano di Cardiologia  
Medical research and consequently therapy are undergoing dramatic transformation. New science on genomics and proteomics has given us important information on the pathophysiology of many cardiac diseases and personalized responses to specific patient-oriented therapies. The application of cellular genetic and proteome tests is a promising field of research and their clinical use can allow us to both: 1) understand the causes and evolution of heart diseases such as ischemia and heart failure
more » ... er, 2) lead to personalized medicine. This article focuses on the basic intracellular-related evidence and the unsolved problems and complexity of intracellular signaling that still need to be studied to understand personalized therapies better. In addition, we provide preliminary clinical data that support the potentiality of this new but fundamental approach of curing patients according to their genetic expression and/or protein activation that influence personalized development and the management of cardiovascular diseases.
pmid:21246777 fatcat:3f3ikek2trdxzj6rwr5ytsm2va