Anesthetics, Cerebral Protection and Preconditioning

Rogean Rodrigues Nunes, Gastão Fernandes Duval Neto, Júlio César Garcia de Alencar, Suyane Benevides Franco, Nayanna Quezado de Andrade, Danielle Maia Holanda Dumaresq, Sara Lúcia Cavalcante
2013 Brazilian Journal of Anesthesiology  
and objectives: Several studies demonstrate that cerebral preconditioning is a protective mechanism against a stressful situation. Preconditioning determinants are described, as well as the neuroprotection provided by anesthetic and non-anesthetics agents. Content: Review based on the main articles addressing the pathophysiology of ischemia-reperfusion and neuronal injury and pharmacological and non-pharmacological factors (infl ammation, glycemia, and temperature) related to the change in
more » ... nse to ischemia-reperfusion, in addition to neuroprotection induced by anesthetic use. Conclusions: The brain has the ability to protect itself against ischemia when stimulated. The elucidation of this mechanism enables the application of preconditioning inducing substances (some anesthetics), other drugs, and non-pharmacological measures, such as hypothermia, aimed at inducing tolerance to ischemic lesions.
doi:10.1016/j.bjane.2012.06.003 pmid:24565096 fatcat:xucg2k7ynbfshdxcr3cyckst44