Lead is considered as one of the major environmental pollutants that continued to pose health hazards in animal and man in many parts of the world. The current study aimed to investigate the histological effects of corn oil, flaxseed oil and black seed oil against lead acetate-induced hepatic tissue damage in mice. Animals were divided into five groups. The first group served as a control group. The second group was inoculated with 20 mg/kg lead acetate. The third, fourth and fifth groups were

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... noculated with lead acetate then, treated with 1000 mg/kg of corn oil, flaxseed oil and black seed oil, respectively. At day 5 post-treatment, the liver sections were prepared for the histological study. Lead acetate induced severe hepatic tissue damage mainly in the form of inflammatory cellular infiltration, hepatocytic vacuolation and sinusoidal dilatation. Mice treated with corn oil for 5 days still have histopathological lesions. Both flaxseed oil and black seed oil could reduce the lead acetate-induced hepatic tissue damage.