A total of 62 Streptomyces were isolated from the farm land and waste land of Kogi central and screened for their antimicrobial activities. They were evaluated for their antagonistic activities on seven test organisms. Eighteen Streptomyces isolates which exhibit antimicrobial activity against at least 5 of the test organisms were characterized by conventional methods. The cultural characteristic was then studied. The result indicates that 9 (nine) isolates were highly active against

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... ve bacteria. 6(six) isolates were highly active against a fungus with a zone of inhibition greater than >14mm in diameter. Most of the isolates inhibited growth of the Gram negative bacteria tested. All the antibiotic producing Streptomyces were isolated at different location from agricultural and non-agricultural waste land. Eighteen isolates shows antimicrobial effect against six bacteria and a fungus. With these findings, it is suggestive that Kogi central soil and it environ is a good source to explore potent antibiotics against clinically resistant pathogens.