Formulation and Development of a Curcumin-Piperine Loaded Nanoemulsion for the Treatment of Alzheimer's Disease [post]

Shmmon Ahmad, Abdul Hafeez
2022 unpublished
Background and Objective: Curcumin (Cur) and piperine (Pip) are very well-known phytochemicals that claimed to have many health benefits and have been widely used in foods and traditional medicines. This study investigated the therapeutic efficacy of these compounds to treat Alzheimer's disease (AD). However, poor oral bioavailability and permeability of curcumin are a major challenge for formulation scientists. In this research study, the researcher tried to enhance the bioavailability &
more » ... bility of curcumin by a nanotechnological approach. Materials and Methods In this research study, we developed a Cur-Pip-loaded SNEDDS in various oils. Optimized formulation NF3 was subjected to evaluate its therapeutic effectiveness on AD animal model in comparison with untreated AD model and treated group (by market formulation donepezil). Results On the basis of characterization results it is confirmed that NF3 formulation is the best formulation. The optimized formulation shows a significant dose-dependent manner therapeutic effect on AD-induced model Conclusion Novel formulation Cur-Pip Solid-SNEDDS was successfully developed and optimized. It's expected developed S-SNEDDS can be a potential, safe and effective carrier for the oral delivery of curcumin to the brain. This research article first reported the bio-active S-SNEDDS of Cur-Pip effect on Alzheimer's.
doi:10.21203/rs.3.rs-1712519/v1 fatcat:djhlpwababddva4vopjxvryeum