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A relatively bloodless microscopic field is essential to facilitate surgical exposure in Simple Middle Ear Surgery (SMES). Our aim was to compare dexmedetomedine with midazolam in reducing bleeding in SMES performed under local anesthesia. Methods: In this prospective, double-blind, comparative study, 54 patients undergoing SMES randomly received intravenous sedative infusion of either: Dexmedetomedine (Group D) or midazolam (Group M) titrated to a bispectral index reading of 70-80. Pain ondoi:10.1016/j.egja.2011.12.004 fatcat:n5xuqwh64ngh7o5u3t7zqwygki