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Exploring background mutational processes to decipher cancer genetic heterogeneity
2017
Nucleic Acids Research
Much remains unknown about the progression and heterogeneity of mutational processes in different cancers and their diagnostic and clinical potential. A growing body of evidence supports mutation rate dependence on the local DNA sequence context for various types of mutations. We propose several tools for the analysis of cancer context-dependent mutations, which are implemented in an online computational framework MutaGene. The framework explores DNA context-dependent mutational patterns and
doi:10.1093/nar/gkx367
pmid:28472504
pmcid:PMC5793731
fatcat:zrliuqo4l5godawceqfhsfqfyu