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One-pot, regioselective synthesis of functionalized indole derivatives: a three-component domino reaction of arylamine, arylglyoxal, and 4-hydroxycoumarin or 4-hydroxy-6-methyl-2-pyrone
2020
ARKIVOC
A metal free, one-pot tandem synthetic routes for functionalized indole derivatives has been established. An efficient three-component reaction was designed with incorporation of Knoevenagel condensation followed by inter-, and intramolecular nucleophilic addition reaction in one-pot under mild condition. The structural diversities of the synthesized compounds have been confirmed spectroscopically, by IR, 1 H-and 13 C NMR, and elemental analyses which agree with the proposed structures. Figure
doi:10.24820/ark.5550190.p011.151
fatcat:iwiu6paskbgmthqn2ilmkistga