and Aim: The coronavirus disease 2019 (COVID-19) vaccine helps to develop immunity to SARS-CoV-2, the virus that causes COVID-19, in most cases preventing the disease. Although various brands of vaccines work in different modes, all COVID-19 vaccines prompt an immune reaction to make the body remembers how to protect from the virus in the future. The present study aims to evaluate the safety and the immune response for mixing of Sputnik V and AstraZeneca COVID-19 vaccines on mice. Materials and

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... Methods: Our experimental study was performed on mice weighing on average of 20 g, selected by random allocation. The mice were divided into four groups of 12. Group one received a single dose of 0.5 ml Sputnik V COVID-19 vaccine, group two received two doses of 0.5 ml AstraZeneca COVID-19 vaccine, group three received two doses of 0.5 ml Sputnik V together with 0.5 ml AstraZeneca COVID-19 vaccine and group four received two doses of 0.5 ml of 0.9 % NaCl. Results: Our study shows that mixing of Sputnik V and AstraZeneca COVID-19 vaccines is safe and induces good immunity for mice. Conclusion: Mixing of Sputnik V and AstraZeneca COVID-19 vaccines creates no problems and provides good immunity to mice and may be an interesting technique to help to overcome shortcomings of one or the other vaccine. Further toxicity studies are required to assess potential hazards for humans to evaluate the histopathological characteristics.