Impact of Multimodality Imaging to Improve Radiation Therapy (RT) Target Volume Definition for Malignant Peripheral Nerve Sheath Tumor (MPNST)

Ferrat Dincoglan
2021 Biomedical Journal of Scientific & Technical Research  
Objective: Extensive effort has been focused on improving the toxicity profile of radiation delivery for malignant peripheral nerve sheath tumor (MPNST). Radiation therapy (RT) planning for MPNST is typically based on computed tomography (CT)simulation. Nevertheless, incorporation of supplementary imaging modalities may offer great potential for improving radiotherapeutic management. Herein, we evaluated the impact of multimodality imaging to improve RT target volume definition for MPNST.
more » ... on for MPNST. Materials and Methods: RT target volume definition for MPNST with incorporation of magnetic resonance imaging (MRI) or by use of the CT-simulation images only has been comparatively assessed. Ground truth target volume which has been utilized as the reference for actual treatment and comparison purposes was thoroughly determined by the board certified radiation oncologists after meticulous evaluation, colleague peer review, collaboration, and ultimate consensus. Results: RT planning has been accomplished by use of precise treatment planning systems at our tertiary referal institution. Primary objectives of RT planning included adequate coverage of target volumes with optimal sparing of critical structures. Synergy (Elekta, UK) Linear Accelerator has been utilized for delivery of irradiation. Results of our study revealed that ground truth target volume was identical with target volume determination with CT-MR fusion based imaging. Conclusion: RT target definition composes an indispensable aspect of successful radiotherapeutic management for MPNST. Incorporation of MRI in target volume definition is strongly recommended for improved accuracy and precision in radiotherapeutic management of MPNST despite the need for further supporting evidence.
doi:10.26717/bjstr.2021.34.005549 fatcat:xlyu5s2itjfmbfgzo5kh64aypa