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In this study we tried to determine when in relation to meals gliclazide should be taken for optimum hypoglycemic action. Eight non-insulin-dependent diabetics participated in this study during hospitalization for glycemic control. After stabilization of glycemic control on gliclazide, they took a 40 mg tablet of gliclazide either 30 minutes before, immediately before, or immediately after breakfast on 3 consecutive days. We then determined serum gliclazide, glucose and IRI levels at 30-minutespmid:2373640 fatcat:kvs6koy74valfp5zspyfucosvy