Objective: To assess the effectiveness of Aprepitant (NK-1 receptor antagonist) for prophylaxis of postoperative nausea and vomiting in middle aged female patients undergoing laparoscopic cholecystectomy under General Anesthesia. Study Design: Quasi-experimental study. Place and Duration of Study: Combined Military Hospital Lahore, from Jun 2018 to Dec 2018. Methodology: Four hundred American Society of Anesthesiologists (ASA) I and II middle aged female patients undergoing laparoscopic

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... tectomy under general anesthesia were recruited. Patients were divided into two groups of 200 each as "A" (Aprepitant) and "P" (Placebo). Forty miligrams Aprepitant was given to A-group patients, whereas P-group was given empty capsule. Patients were given standardized general anesthesia and were observed and documented for incidence and severity of early (0-2 hours) and delayed (2-24 hours) periods for episodes of postoperative nausea and vomiting. Results: In A-group 20 (10%) had nausea, 8 (4%) had vomiting. Only 4 (2%) needed rescue anti-emetic. In P-group 84 (42%) had nausea and 76 (38%) had vomiting, 21 (10.5%) needed rescue antiemetic. The difference between the two groups was found statistically significant. Conclusion: Preemptive use of Aprepitant (NK-1 receptor antagonist) reduces the incidence of postoperative nausea and vomiting and need for rescue anti-emetic.