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Rationale and Objectives: To investigate the transport of the hepatobiliary magnetic resonance (MR) imaging contrast agent Gd-BOPTA into rat hepatocytes. Materials and Methods: In a MR-compatible hollow-fiber bioreactor containing hepatocytes, MR signal intensity was measured over time during the perfusion of Gd-BOPTA. For comparison, the perfusion of an extracellular contrast agent (Gd-DTPA) was also studied. A compartmental pharmacokinetic model was developed to describe dynamic signaldoi:10.1097/01.rli.0000129156.16054.30 pmid:15257212 fatcat:2pbm5sitbbakpbbpw36nxrenau