PERISCOPE 591 paralysis (agitated and hallucinatory forms) is not satisfactory. Sleep conies slowly, is irregular, of short duration. In depressed and simple de¬ mented forms of paresis the authors have not had sufficient experience. Even in doses of i.o they never found disagreeable symptoms which could be attributed to the drug. There was no modification of the pulse, no alteration of cardiac murmurs; old people, even those with cardiac lesion, bore the drug well. Albuminuria was never

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... d. In only one case out of forty was there a marked intolerance. The drug was often given for long periods night after night. They regard is as the most serviceable of hypnotics. 3. Sclerotic Atrophy of Left Hemisphere.-On account of the re¬ markable accuracy in observation extending over years and including the parents, as well as the very careful autopsy, study of this case is of interest. The points are the first convulsions at six months in an infant supposedly normal, followed by a transitory hemiparesis (right). At ten months a second period of illness occurred with similar convulsions and paresis, with respite until the fourteenth month. After this convulsions every six months until the second year. After about the seventh year the fits became more frequent, and finally, at about eight years occurred daily. Intelligence diminished, and finally dementia ensued. The char¬ acter upon admittance (eight years and four weeks) was noticeably ex¬ pansive, but became more and more suspicious, irritable and violent.. The authors note that the ability to calculate and write disappeared before that of reading, which also finally went. Autopsy showed generalized tuberculosis of both lungs and the kid¬ neys. Skull: Persistence of the sutures, great thickening of the bones, left side. Encephalon marked difference in weight of the two hemis¬ pheres, the left 200.0 less. General atrophy left cerebrum, convolutions pale, indurated, thinner; atrophy most marked over the frontal and occipi¬ tal lobes. Also on the left side the optic nerve, the optic radiation, the mammillary body, the cerebral peduncle, the corpus striatum and the thala¬ mus were all diminished in volume. Besides, the left hemisphere pre¬ sented a chronic meningitis. The cerebellum was also smaller. Changes in the right brain were of small moment. There was a partial epilepsy of hemiplegic type due to the sclerotic atrophy and the chronic menin¬ gitis of the left hemisphere. The thickening of the skull on the left side was a sort of compensatory process following atrophy of the left hemisphere. There was dilatation of the left lateral ventricle without increase of fluid. The authors conclude that the hemiplegic type of epi¬ lepsy with meningo-encephalitis or with chronic meningitis is in every way similar to that form of epilepsy which terminates in dementia. Wolfstein (Cincinnati).