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Efficient electrospray ionization from polymer microchannels using integrated hydrophobic membranes
Lab on a Chip
A simple process for realizing stable and reliable electrospray ionization (ESI) tips in polymer microfluidic systems is described. The process is based on the addition of a thin hydrophobic membrane at the microchannel exit to constrain lateral dispersion of the Taylor cone formed during ESI. Using this approach, ESI chips are shown to exhibit well-defined Taylor cones at flow rates as low as 80 nL min 21 through optical imaging. Furthermore, stable electrospray current has been measured fordoi:10.1039/b402825b pmid:15269805 fatcat:4fgin4jm6va3xpku7esf54drri