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Myeloperoxidase and oxidation of uric acid in gout: implications for the clinical consequences of hyperuricaemia
Objectives. The aims of this study were to establish whether, in patients with gout, MPO is released from neutrophils and urate is oxidized to allantoin and if these effects are attenuated by allopurinol. Methods. MPO, urate, allantoin and oxypurinol were measured in plasma from 54 patients with gout and 27 healthy controls. Twenty-three patients had acute gout, 13 of whom were receiving allopurinol, and 31 had intercritical gout, 20 of whom were receiving allopurinol. Ten additional goutdoi:10.1093/rheumatology/keu218 pmid:24899662 fatcat:h7rbuymjwjc55fd4heamq4fa5m