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The article presents a successful experience of complex multi-stage surgical treatment of a severe open comminuted fracture of the humerus with large detachment and crushing of the soft tissues of the upper limb. Special attention was paid to approaches to performance of staged surgical treatment and preparation of the wound to plastic closing, state-of-art treatment methods that include negative pressure wound therapy (NPWT), treatment of wounds with a "pulsating liquid jet", use ofdoi:10.25199/2408-9613-2014-1-2-44-50 fatcat:z4awdlyf2nhv3bixn6w73q2voe