The article presents a successful experience of complex multi-stage surgical treatment of a severe open comminuted fracture of the humerus with large detachment and crushing of the soft tissues of the upper limb. Special attention was paid to approaches to performance of staged surgical treatment and preparation of the wound to plastic closing, state-of-art treatment methods that include negative pressure wound therapy (NPWT), treatment of wounds with a "pulsating liquid jet", use of

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... means for the topical treatment of wounds. The whole complex of the proposed surgical and conservative methods allowed transferring of the wound process from the complicated to the normal category, reposition and closing of the fracture area with fully functional soft tissues, complete elimination of the extensive injury of the upper extremity in a functionally active region, to a greater extent at the expense of local surrounding tissues, as well as achievement of the good functional and cosmetic effect.