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AbstractSolving the chemical master equation exactly is typically not possible, so instead we must rely on simulation based methods. Unfortunately, drawing exact realisations, results in simulating every reaction that occurs. This will preclude the use of exact simulators for models of any realistic size and so approximate algorithms become important. In this paper we describe a general framework for assessing the accuracy of the linear noise and two moment approximations. By constructing andoi:10.1515/sagmb-2014-0071 pmid:27682714 fatcat:7e2bl7marrb77jhe4z2u7dbxxa