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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage
2020
Cell
Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome is protected against mechanical stress is unclear. We show that mechanical stretch deforms the nucleus, which cells initially counteract via a calcium-dependent nuclear softening driven by loss of H3K9me3-marked heterochromatin. The resulting changes in chromatin rheology and architecture are required to
doi:10.1016/j.cell.2020.03.052
pmid:32302590
pmcid:PMC7237863
fatcat:rwpwyhbigbftrbtwpl4v2d47re