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The prediction of protein three-dimensional structure from amino acid sequence has been a grand challenge problem in computational biophysics for decades, owing to its intrinsic scientific interest and also to the many potential applications for robust protein structure prediction algorithms, from genome interpretation to protein function prediction. More recently, the inverse problem - designing an amino acid sequence that will fold into a specified three-dimensional structure - has attracteddoi:10.1038/s41580-019-0163-x pmid:31417196 pmcid:PMC7032036 fatcat:yw2q2q5dajh5bdsm5krjsbt4v4