Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms

Bala Sekaran Chandra, Siva Santhosh Bhogela, Manjusha Shaik, Chaitanya Sravanthi Vadlamudi, Meghana Chappa, Naga Sirisha Maddirala
2011 Química Nova  
Recebido em 26/10/10; aceito em 30/1/11; publicado na web em 1/4/11 Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and α-naphthol and method C is based on the reaction of the drug with vanillin, in acidic
more » ... medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 µg mL -1 by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.
doi:10.1590/s0100-40422011000600026 fatcat:smqjr7saozhkvl4rsglsvbda2q