Laboratory and clinical characteristics of patients diagnosed with HELLP syndrome due to microangiopathic hemolytic anemia and/or thrombocytopenia

Ömer Ekinci, Senar Ebinç
2020 Van Medical Journal  
Objective: We aimed to present the pregnant patients who were consulted with hematologists for microangiopathic hemolytic anemia and/or thrombocytopenia and were diagnosed HELLP syndrome. Materials and Methods: A total of 32 patients, who were diagnosed with HELLP syndrome, were included in this study. Patients with other microangiopathic hemolytic anemia, including pre-eclampsia, eclampsia, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, disseminated intravascular coagulation
more » ... c. were excluded. Results: The median age of all patients was 30. 45 ± 16.22 (18-52) years. According to the Mississippi classification; 12 patients (37.5%) were in class 1 while 15 patients (46.9%) were in class 2, and there was acute renal failure in 4 patients (33.3%) in class 1 and 3 patients (20%) in class 2. There was no acute renal failure present in the class 3 including a total of 5 patients (15.6%). There was renal failure in 6 (42.9%) of 14 patients (43.7%) with HELLP syndrome, whose hemoglobin value was less than or equal to 8 gr/dl. In patients with HELLP syndrome, the renal failure risk of those whose hemoglobin value was less than or equal to 8 gr/dl was significantly higher than those whose hemoglobin value was greater than 8 gr/dl (OR: 12.75, p = 0.0285). Conclusion: The mechanism of occurrence of HELLP syndrome is not clear and have many overlapping clinical aspects with the other thrombotic microangiopathic syndromes. Renal failure is a complication of HELLP syndrome. The most associated cases with renal failure are the presence of DIC and severe anemia in HELLP syndrome. The hemoglobin value of less than 8 gr/dl is a significant risk factor for renal failure in HELLP syndrome.
doi:10.5505/vtd.2020.57984 fatcat:drr36mc5lrhbvcrgc3jypjgoyq