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Mechanisms regulating zygotic genome activation
2018
Nature reviews genetics
Following fertilization, the two specified gametes must unite to create an entirely new organism. The genome is initially transcriptionally quiescent, allowing the zygote to be reprogrammed into a totipotent state. Gradually, the genome is activated through a process known as the maternal-to-zygotic transition, which enables zygotic gene products to replace the maternal supply that initiated development. This essential transition has been broadly characterized through decades of research in
doi:10.1038/s41576-018-0087-x
pmid:30573849
pmcid:PMC6558659
fatcat:s5qv7t74ubeqdho4o27hyc7duu