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Spatial Multiomics Analysis Identifies SOCS1 as a Key Immune Checkpoint in T cell Tolerance Induction of HSCT
Achieving T cell tolerance ensures superior clinical outcomes in hematopoietic stem cell transplantation (HSCT). However, the in vivo T cell tolerance profiles in physiological state need to be further delineated. Here, we characterized the gene expression profile in tolerant T cells which was induced in healthy donors by granulocyte colony-stimulating factor, a stem cell mobilizer extensively used in HSCT. We identified suppressor of cytokine signaling 1 (SOCS1) as an essential immunedoi:10.21203/rs.3.rs-150508/v1 fatcat:pb6zvjh3orb35eslfu5kv5cclm