Multiple Sclerosis

Daniel S. Reich, Claudia F. Lucchinetti, Peter A. Calabresi, Dan L. Longo
<span title="2018-01-11">2018</span> <i title="New England Journal of Medicine (NEJM/MMS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/td5cjnem25b35nugn4qftmwcna" style="color: black;">New England Journal of Medicine</a> </i> &nbsp;
Pathology The pathological conception of MS as a disseminated "plaque-like sclerosis" was established ~150 years ago; indeed, the demonstration of dissemination -in space (diseaserelated changes in multiple CNS regions, including white matter, gray matter, brainstem, spinal cord, and optic nerve; Figure 1 ) and time -forms the cornerstone of MS diagnosis. Our understanding of the details of that pathology, and especially how it evolves over time,
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