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Multiple Sclerosis
<span title="2018-01-11">2018</span>
<i title="New England Journal of Medicine (NEJM/MMS)">
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Pathology The pathological conception of MS as a disseminated "plaque-like sclerosis" was established ~150 years ago; indeed, the demonstration of dissemination -in space (diseaserelated changes in multiple CNS regions, including white matter, gray matter, brainstem, spinal cord, and optic nerve; Figure 1 ) and time -forms the cornerstone of MS diagnosis. Our understanding of the details of that pathology, and especially how it evolves over time,
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