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Regulation of Enzyme Synthesis in the Aromatic Amino Acid Pathway of Bacillus subtilus
Journal of Bacteriology
The control of the synthesis of certain key enzymes of aromatic amino acid biosynthesis was studied. Tyrosine represses the first enzyme of the 3-deoxy-D-arabino heptulosonic acid 7-phosphate pathway, DAHP synthetase, as well as shikimate kinase and chorismate mutase about fivefold in cultures grown under conditions limiting the synthesis of the aromatic amino acids. A mixture of tyrosine and phenylalanine represses twofold further. Tryptophan does not appear to be involved in the control ofdoi:10.1128/jb.97.1.83-90.1969 fatcat:yoe3g55dtzaobdmmrxtr4mkpaa