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Three-dimensional experiments and individual based simulations show that cell proliferation drives melanoma nest formation in human skin tissue
Melanoma can be diagnosed by identifying nests of cells on the skin surface. Understanding the processes that drive nest formation is important as these processes could be potential targets for new cancer drugs. Cell proliferation and cell migration are two potential mechanisms that could conceivably drive melanoma nest formation. However, it is unclear which one of these two putative mechanisms plays a dominant role in driving nest formation. We use a suite of three-dimensional (3D)doi:10.1101/244582 fatcat:56vfikhzfjdkpnk5n7w3ytg62y