Objective of research: The development of new methods of complex treatment and prevention of common scab of sheep. Materials and methods: Medical treatment was provided to 60 sheep from a sheep farm of Khasavyurt region spontaneously infected with Psoroptes ovis. Sheep were divided into three groups, 20 head in each. The animals of the first group received once subcutaneously Ivermec at the dose of 1,0 ml per 50kg of body mass, and Roncoleukin at the dose of 5000 IU/kg. The animals of the

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... group were injected subcutaneously with Ivomec at the dose of 1,0/50 kg of body mass. The third group served as control and did not receive the preparation. Before and 12, 40, 60 and 70 days after treatment, we took skin scrapings from sheep of all three groups and conducted an acarological research for the presence of ticks Psoroptes ovis. The obtained results were processed statistically with the use of the computer program «Biometry» Results and discussion: The single subcutaneous use of Ivermec at the dose of 0,2 mg/kg of animal's body mass + Roncoleukin at the dose of 5000 IU/kg of body mass enables to prevent common scab of sheep on average within 65-70 days, and Ivomec at the dose of 0,2 mg/kg applied subcutaneously - within 37-40 days. According to the results of sheep shearing conducted after 65-70 days of drug injection, a small number of foci of the size 2-5 cm was found in sheep of the first group. The infestation occurred approximately 60-70 days after the single subcutaneous administration of Ivermec at the dose of 0,2 mg/kg + Roncoleukin at the dose of 5000 IU/kg. Multiple foci of the size 5-10 cm were detected in sheep of the second group. Infestation took place approximately 37-40 days after Ivomec injection. In sheep of the third group a generalized form of common scab was registered.