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Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis
Lymph nodes (LNs) are a common site of metastasis in solid cancers, and cutaneous melanomas show inherent properties of LN colonization. However, interactions between LN stroma and pioneer metastatic cells during metastatic colonization remain largely uncharacterized. Here we studied mice implanted with GFP-expressing melanoma cells to decipher early LN colonization events. We show that Siglec1-expressing subcapsular sinus (SCS) macrophages provide anchorage to pioneer metastatic cells. Wedoi:10.7554/elife.48916 pmid:31872800 fatcat:awxrcbgrmzgynnpjpgnmusdxru