Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia

William E. Klunk
2011 Neurobiology of Aging  
Since the introduction of amyloid imaging nearly ten years ago, this technique has gained widespread use and acceptance. More recently, published reports have begun to appear in which amyloid imaging is used to detect the effects of anti-amyloid therapies. This review will consider the issues involved in the use of amyloid imaging in the development and evaluation of drugs for the treatment of Alzheimer disease. Current evidence regarding the postmortem correlates of in vivo amyloid imaging
more » ... is considered. The application of amyloid imaging to screening subjects for trials and use as an outcome measure is discussed in light of longitudinal changes in the in vivo amyloid signal. While the bulk of this review is directed at symptomatic patients with dementia, consideration is given to the use of amyloid imaging in non-demented subjects as well. Similarities and differences of cerebral amyloid assessment by amyloid imaging and CSF measurements are delineated and an agenda for further research to improve the applicability of amyloid PET to clinical trials is proposed.
doi:10.1016/j.neurobiolaging.2011.09.006 pmid:22078170 pmcid:PMC3233688 fatcat:al4u3hp2prb45hd4i2ryurpppy