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Genetic and Epigenetic Analysis of the Putative Tumor Suppressor km23 in Primary Ovarian, Breast, and Colorectal Cancers
Clinical Cancer Research
Purpose: A very high frequency of somatic mutations in the transforming growth factor-h signaling component km23 has been reported in a small series of ovarian cancers (8 of 19, 42%). Functional studies showed that some mutations disrupt km23 function, resulting in aberrant transforming growth factor-h signaling and presumably enhanced tumorigenicity. If verified, this would elevate mutation of km23 as the single most frequent somatic event in ovarian cancer. Experimental Design: We sought todoi:10.1158/1078-0432.ccr-06-0800 pmid:16778097 fatcat:m6goawvvnbakpmps3idoqrr5au