Synthesis and cytotoxicity of new 4-aza-2,3-didehydropodophyllotoxins

Nguyen Thi Thuy Hang, Tran Thi Yen, Vu Dinh Hoang, Ngo Quoc Anh
2022 Vietnam Journal of Science and Technology  
Five new 4-aza-2,3-didehydropodophyllotoxins were synthesized by a straightforward multi-component reaction in the hope of finding new structures with interesting anticancer activity. The "one-pot" synthesis process is developed to increase performance as well as minimize the steps involved. The obtained compounds with podophyllotoxin frame have the corresponding yields of 60-83%. Five new 4-aza-2,3-didehydropodophyllotoxins demonstrated comparable cytotoxicity against the Hep-G2, MCF7cell
more » ... with an IC50 value of 52.2 - 261.2 µM with ellipsitine as the positive control.
doi:10.15625/2525-2518/15577 fatcat:jclzwkvuhnem3phlyymwuaxwrm