Antioxidative and Anti-aging Effects of Extract from Talinum paniculatum
토인삼 추출물의 항산화 및 항노화 효과

Jung Young Oh, Jin Hwa Kim, Geun Soo Lee, Yong He Zhang, Hyeong Bae Pyo
2013 Journal of the Society of Cosmetic Scientists of Korea  
Ultraviolet irradiation in the cells and skin produces reactive oxygen species (ROS), which induces the synthesis of matrix metalloproteinases (MMPs) causing skin photoaging. Using the human dermal fibroblast (HDF), we investigated the antioxidative and anti-aging effects of the extracts from Talinum paniculatum. Talinum paniculatum leaf and stem extracts (LSE) showed free radical scavenging effect by 98.45% at 500 μg/mL and superoxide radical scavenging effect by 97.01% at 500 μg/mL in the
more » ... hine/xanthine oxidase system. The photoprotective potential of LSE was tested in HDF exposed to ultraviolet irradiation. It was revealed that LSE had an inhibitory effect on MMP-1 expression in UVA-irradiated HDF without any significant cytotoxicity. The treatment of UVA-irradiated HDF with LSE resulted in dose-dependent decreases in the expression levels of MMP-1 mRNA and protein. Also, UVB-induced cytotoxicity and cell death were effectively suppressed by treatment of LSE. Additionally, the senescence-associated βgalactosidase (SA-β-gal) activity was decreased in the presence of LSE. These results suggest that Talinum paniculatum leaf and stem extracts (LSE) may have anti-aging effects and can be used as new functional materials against oxidative stress-mediated skin damages.
doi:10.15230/scsk.2013.39.4.313 fatcat:ey2ot6bqvnbpvgua62amj4dipm