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Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials

Phiwayinkosi V. Dludla, Patrick Orlando, Sonia Silvestri, Fabio Marcheggiani, Ilenia Cirilli, Tawanda M. Nyambuya, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Bongani B. Nkambule, Rabia Johnson, Sithandiwe E. Mazibuko-Mbeje, Christo J. F. Muller (+2 others)
2020 International Journal of Molecular Sciences  

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Evidence from randomized controlled trials (RCTs) suggests that coenzyme Q10 (CoQ10) can regulate adipokine levels to impact inflammation and oxidative stress in conditions of metabolic syndrome. Here, prominent electronic databases such as MEDLINE, Cochrane Library, and EMBASE were searched for eligible RCTs reporting on any correlation between adipokine levels and modulation of inflammation and oxidative stress in individuals with metabolic syndrome taking CoQ10. The risk of bias was assessed
more » ... using the modified Black and Downs checklist, while the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to evaluate the quality of evidence. Results from the current meta-analysis, involving 318 participants, showed that CoQ10 supplementation in individuals with metabolic syndrome increased adiponectin levels when compared to those on placebo (SMD: 1.44 [95% CI: −0.13, 3.00]; I2 = 96%, p < 0.00001). Moreover, CoQ10 supplementation significantly lowered inflammation markers in individuals with metabolic syndrome in comparison to those on placebo (SMD: −0.31 [95% CI: −0.54, −0.08]; I2 = 51%, p = 0.07). Such benefits with CoQ10 supplementation were related to its ameliorative effects on lipid peroxidation by reducing malondialdehyde levels, concomitant to improving glucose control and liver function. The overall findings suggest that optimal regulation of adipokine function is crucial for the beneficial effects of CoQ10 in improving metabolic health.
doi:10.3390/ijms21093247 pmid:32375340 fatcat:rs65dgpzezeovph64b3r2lkbcu
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Phiwayinkosi V. Dludla, Patrick Orlando, Sonia Silvestri, Fabio Marcheggiani, Ilenia Cirilli, Tawanda M. Nyambuya, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Bongani B. Nkambule, Rabia Johnson, Sithandiwe E. Mazibuko-Mbeje, Christo J. F. Muller, Johan Louw, Luca Tiano. "Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials." International Journal of Molecular Sciences 21.9 (2020) 3247