Individual variation in response to high intensity interval training among participants with newly diagnosed type 2 diabetes

A. McCann, K. Backx, D. Wasley, G. Dunseath, S. Luzio, D. Owens
2012 Proceedings of the Nutrition Society  
Most studies evaluating the efficacy of exercise tend to overlook inter-individual variability (1) . The aim of the present study was to investigate the effect of 12 weeks of high intensity interval training on metabolic control, beta-cell secretion and insulin resistance among ten individuals with newly diagnosed type 2 diabetes. Baseline measures included body composition, glycosylated haemoglobin (HbA 1c ), lipid profile and tests performed were meal tolerance test (MTT) and frequently
more » ... nd frequently sampled intravenous glucose tolerance test (FSIVGTT). Measures of fasting (M 0 ) and postprandial (M 1 ) beta-cell responsiveness, and acute insulin response to glucose (AIR g ) were determined and HOMA-IR calculated as a measure of insulin resistance. Interval training was scheduled 3 times . week -1 and used individualized exercise intensities determined using the heart rate reserve (HRR) method. Following an introductory phase during weeks 1 and 2, training progressed to 20-40 min periods of interval training consisting of low-intensity periods of 1-2 min at 40-50% HRR and high-intensity periods of 1, 2 or 3 min at 80-90% HRR (weeks 3-12). All baseline measurements and tests were repeated post intervention. Average [range] compliance was observed as 63.0[38.9-80.5] % at an intensity of 77.3[65.8-86.5]% HRR. Group analysis indicated there were significant changes following intervention in BMI (30.0 vs. 28.7 kg.m -2 ; p = 0.006), waist circumference (101.4 vs. 97.2 cm; p = 0.021), HbA 1c (6.4 vs. 6.0%; p = 0.007), total cholesterol (5.3 vs. 4.6 mmol.L -1 ; p = 0.046), low-density lipoprotein (LDL) cholesterol (3.2 vs. 2.6 mmol.L -1 ; p = 0.028), M 0 (11.5 · 10 -9 vs. 7.0 · 10 -9 pmol.kg -1 .min -1 ; p = 0.009), AIR g (20.4 vs. 27.2; p = 0.05) and HOMA-IR (3.0 vs. 2.1; p = 0.049). However, the Table below illustrates that within the group there were also considerable variations in response to interval training both among individuals and among the measured parameters.
doi:10.1017/s0029665112002431 fatcat:hcw75dmwtzdpjfw654n76xvkoi