Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated fromPiper longumon Melanin Production in B16 Mouse Melanoma Cells

Osamu OHNO, Taeko WATABE, Kazuhiko NAKAMURA, Masaru KAWAGOSHI, Nobuo UOTSU, Tomohiro CHIBA, Masayoshi YAMADA, Kohji YAMAGUCHI, Kaoru YAMADA, Kenji MIYAMOTO, Daisuke UEMURA
2010 Bioscience, biotechnology and biochemistry  
An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against -melanocyte-stimulating hormone (-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassaydirected fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.
doi:10.1271/bbb.100221 pmid:20622433 fatcat:vll7q4yxgrbxzo3727m6epyy6e