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Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated fromPiper longumon Melanin Production in B16 Mouse Melanoma Cells
2010
Bioscience, biotechnology and biochemistry
An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against -melanocyte-stimulating hormone (-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassaydirected fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.
doi:10.1271/bbb.100221
pmid:20622433
fatcat:vll7q4yxgrbxzo3727m6epyy6e