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This review deals with different aspects of driving under the influence of drugs (DUID).Cannabis, cocaine, opiates, amphetamines and methamphetamines are the most prevalent illegal drugs detected in the surveys carried out by the police and involved in traffic accidents. The use of oral fluid matrix to detect drugged drivers as well as pharmacokinetics of illegal drugs in oral fluid, correlation with blood, times of elimination and on-site drugs tests has been considered. A brief description ofdoi:10.6084/m9.figshare.5669413.v1 fatcat:vunxo3m5jbgatkfzd3ch7pqxsa